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Article: Breaking Down the Science: A Comprehensive Literature Review on NAD+ Studies

Breaking Down the Science: A Comprehensive Literature Review on NAD+ Studies

Breaking Down the Science: A Comprehensive Literature Review on NAD+ Studies

When it comes to NAD+ and its impact on longevity and cellular health, a plethora of research papers, clinical studies, and reviews abound. But what does the scientific literature actually say? This blog aims to provide a comprehensive review of key studies on NAD+, summarizing findings and shedding light on the current state of research.

The Landmark Studies

The First Observations

The journey of NAD+ research traces back to early biochemical experiments that identified its role in redox reactions. These laid the foundation for understanding NAD+ as an essential cellular component.

NAD+ and Aging

Groundbreaking studies have shown that declining NAD+ levels are closely related to aging and associated conditions. In mouse models, replenishing NAD+ reversed several signs of aging.

Sirtuins and Longevity

Research on yeast, worms, and flies revealed the role of sirtuins, proteins activated by NAD+, in extending lifespan. Subsequent studies in mammals further corroborated these findings.

Current Clinical Trials

Boosting NAD+ Levels

Several clinical trials are investigating the efficacy of NAD+ precursors like nicotinamide riboside and nicotinamide mononucleotide in raising cellular NAD+ levels.

Safety and Side Effects

Current research is also focusing on understanding the potential side effects and safety concerns related to NAD+ supplementation.

Challenges and Limitations

Limited Human Trials

While animal studies show promise, there is a lack of extensive human trials to validate findings.

Inconclusive Evidence on Longevity

Many studies indicate potential benefits in healthspan, but longevity extension in humans remains inconclusive.


The scientific literature on NAD+ offers a wealth of information that underscores its importance in cellular health and longevity. However, more research is needed to fully understand its potential benefits and risks. As science progresses, we can expect more concrete answers to emerge, providing a clearer picture of NAD+'s role in our health and well-being.



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